Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice

The adhesion receptor ADGRA3 (GPR125) is a known spermatogonial stem cell marker, but its impact on male reproduction and fertility has not been examined. Using a mouse model lacking Adgra3 (Adgra3 (−/−)), we show that 55% of the male mice are infertile from puberty despite having normal spermatogen...

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Detalles Bibliográficos
Autores principales: Nybo, Maja L., Kvam, Jone M., Nielsen, John E., Frederiksen, Hanne, Spiess, Katja, Jensen, Kristian H. R., Gadgaard, Sarina, Walser, Anna L. S., Thomsen, Jesper S., Cowin, Pamela, Juul, Anders, Jensen, Martin Blomberg, Rosenkilde, Mette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107928/
https://www.ncbi.nlm.nih.gov/pubmed/36688818
http://dx.doi.org/10.1096/fj.202200762RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107928/
https://www.ncbi.nlm.nih.gov/pubmed/36688818
http://dx.doi.org/10.1096/fj.202200762RR

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