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Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node

Lymph node (LN) lipomatosis is a common but rarely discussed phenomenon associated with aging that involves a gradual exchange of the LN parenchyma into adipose tissue. The mechanisms behind these changes and the effects on the LN are unknown. We show that LN lipomatosis starts in the medullary regi...

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Detalles Bibliográficos
Autores principales: Bekkhus, Tove, Olofsson, Anna, Sun, Ying, Magnusson, Peetra U, Ulvmar, Maria H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108032/
https://www.ncbi.nlm.nih.gov/pubmed/36367235
http://dx.doi.org/10.1002/path.6030