Cargando…
Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node
Lymph node (LN) lipomatosis is a common but rarely discussed phenomenon associated with aging that involves a gradual exchange of the LN parenchyma into adipose tissue. The mechanisms behind these changes and the effects on the LN are unknown. We show that LN lipomatosis starts in the medullary regi...
Autores principales: | Bekkhus, Tove, Olofsson, Anna, Sun, Ying, Magnusson, Peetra U, Ulvmar, Maria H |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108032/ https://www.ncbi.nlm.nih.gov/pubmed/36367235 http://dx.doi.org/10.1002/path.6030 |
Ejemplares similares
-
Remodeling of the Lymph Node High Endothelial Venules Reflects Tumor Invasiveness in Breast Cancer and is Associated with Dysregulation of Perivascular Stromal Cells
por: Bekkhus, Tove, et al.
Publicado: (2021) -
Automated detection of vascular remodeling in tumor‐draining lymph nodes by the deep‐learning tool HEV‐finder
por: Bekkhus, Tove, et al.
Publicado: (2022) -
Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells
por: Arroz-Madeira, Silvia, et al.
Publicado: (2023) -
A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature
por: Xiang, Menglan, et al.
Publicado: (2020) -
Lipomatosis of axillary lymph nodes in a cynomolgus monkey (Macaca
fascicularis)
por: Nakagawa, Minto, et al.
Publicado: (2021)