Bayesian Self‐Optimization for Telescoped Continuous Flow Synthesis

The optimization of multistep chemical syntheses is critical for the rapid development of new pharmaceuticals. However, concatenating individually optimized reactions can lead to inefficient multistep syntheses, owing to chemical interdependencies between the steps. Herein, we develop an automated c...

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Detalles Bibliográficos
Autores principales: Clayton, Adam D., Pyzer‐Knapp, Edward O., Purdie, Mark, Jones, Martin F., Barthelme, Alexandre, Pavey, John, Kapur, Nikil, Chamberlain, Thomas W., Blacker, A. John, Bourne, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108149/
https://www.ncbi.nlm.nih.gov/pubmed/36346840
http://dx.doi.org/10.1002/anie.202214511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108149/
https://www.ncbi.nlm.nih.gov/pubmed/36346840
http://dx.doi.org/10.1002/anie.202214511

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