Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins

[Image: see text] Proteolysis targeting chimeras (PROTACs) represent a new pharmacological modality to inactivate disease-causing proteins. PROTACs operate via recruiting E3 ubiquitin ligases, which enable the transfer of ubiquitin tags onto their target proteins, leading to proteasomal degradation....

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Detalles Bibliográficos
Autores principales: Ng, Yuen Lam Dora, Bricelj, Aleša, Jansen, Jacqueline A., Murgai, Arunima, Peter, Kirsten, Donovan, Katherine A., Gütschow, Michael, Krönke, Jan, Steinebach, Christian, Sosič, Izidor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108347/
https://www.ncbi.nlm.nih.gov/pubmed/36996313
http://dx.doi.org/10.1021/acs.jmedchem.2c01817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108347/
https://www.ncbi.nlm.nih.gov/pubmed/36996313
http://dx.doi.org/10.1021/acs.jmedchem.2c01817

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