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Conserved Conformational Dynamics Reveal a Key Dynamic Residue in the Gatekeeper Loop of Human Cyclophilins
[Image: see text] Cyclophilins are ubiquitous human enzymes that catalyze peptidyl-prolyl cis–trans isomerization in protein substrates. Of the 17 unique isoforms, five closely related isoforms (CypA–E) are found in various environments and participate in diverse cellular processes, yet all have sim...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108351/ https://www.ncbi.nlm.nih.gov/pubmed/36989346 http://dx.doi.org/10.1021/acs.jpcb.2c08650 |