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Conserved Conformational Dynamics Reveal a Key Dynamic Residue in the Gatekeeper Loop of Human Cyclophilins

[Image: see text] Cyclophilins are ubiquitous human enzymes that catalyze peptidyl-prolyl cis–trans isomerization in protein substrates. Of the 17 unique isoforms, five closely related isoforms (CypA–E) are found in various environments and participate in diverse cellular processes, yet all have sim...

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Detalles Bibliográficos
Autores principales: Ahmed, Furyal, Yao, Xin-Qiu, Hamelberg, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108351/
https://www.ncbi.nlm.nih.gov/pubmed/36989346
http://dx.doi.org/10.1021/acs.jpcb.2c08650

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