Expanding the Paradigm of Structure-Based Drug Design: Molecular Dynamics Simulations Support the Development of New Pyridine-Based Protein Kinase C-Targeted Agonists

[Image: see text] Protein kinase C (PKC) modulators hold therapeutic potential for various diseases, including cancer, heart failure, and Alzheimer’s disease. Targeting the C1 domain of PKC represents a promising strategy; the available protein structures warrant the design of PKC-targeted ligands v...

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Detalles Bibliográficos
Autores principales: Lautala, Saara, Provenzani, Riccardo, Tarvainen, Ilari, Sirna, Katia, Karhu, S. Tuuli, Grazhdankin, Evgeni, Lehtinen, Antti K., Sa’d, Hanan, Koivuniemi, Artturi, Xhaard, Henri, Tuominen, Raimo K., Talman, Virpi, Bunker, Alex, Yli-Kauhaluoma, Jari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108360/
https://www.ncbi.nlm.nih.gov/pubmed/37010933
http://dx.doi.org/10.1021/acs.jmedchem.2c01448

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108360/
https://www.ncbi.nlm.nih.gov/pubmed/37010933
http://dx.doi.org/10.1021/acs.jmedchem.2c01448

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