Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors

[Image: see text] Natural glycosaminoglycans (GAGs) are arguably the most diverse collection of natural products. Unfortunately, this bounty of structures remains untapped. Decades of research has realized only one GAG-like synthetic, small-molecule drug, fondaparinux. This represents an abysmal out...

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Detalles Bibliográficos
Autores principales: Abdelfadiel, Elsamani I., Gunta, Rama, Villuri, Bharath Kumar, Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Desai, Umesh R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108365/
https://www.ncbi.nlm.nih.gov/pubmed/37001055
http://dx.doi.org/10.1021/acs.jmedchem.3c00132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108365/
https://www.ncbi.nlm.nih.gov/pubmed/37001055
http://dx.doi.org/10.1021/acs.jmedchem.3c00132

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