Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials

[Image: see text] Clinical development of the antimalarial artefenomel was recently halted due to formulation challenges stemming from the drug’s lipophilicity and low aqueous solubility. The symmetry of organic molecules is known to influence crystal packing energies and by extension solubility and...

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Detalles Bibliográficos
Autores principales: Blank, Brian R., Gut, Jiri, Rosenthal, Philip J., Renslo, Adam R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108391/
https://www.ncbi.nlm.nih.gov/pubmed/37077383
http://dx.doi.org/10.1021/acsmedchemlett.3c00039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108391/
https://www.ncbi.nlm.nih.gov/pubmed/37077383
http://dx.doi.org/10.1021/acsmedchemlett.3c00039

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