Rimonabant-Based Compounds Bearing Hydrophobic Amino Acid Derivatives as Cannabinoid Receptor Subtype 1 Ligands

[Image: see text] In this study, 1H-pyrazole-3-carboxylic acids related to the cannabinoid type 1 (CB1) receptor antagonist rimonabant were amidated with valine or tert-leucine, and the resulting acids were further diversified as methyl esters, amides, and N-methyl amides. In vitro receptor binding...

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Detalles Bibliográficos
Autores principales: Dvorácskó, Szabolcs, Dimmito, Marilisa Pia, Sebastiani, Jessica, La Regina, Giuseppe, Silvestri, Romano, Pieretti, Stefano, Stefanucci, Azzurra, Tömböly, Csaba, Mollica, Adriano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108392/
https://www.ncbi.nlm.nih.gov/pubmed/37077391
http://dx.doi.org/10.1021/acsmedchemlett.3c00024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108392/
https://www.ncbi.nlm.nih.gov/pubmed/37077391
http://dx.doi.org/10.1021/acsmedchemlett.3c00024

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