How a highly acidic SH3 domain folds in the absence of its charged peptide target

Charged residues on the surface of proteins are critical for both protein stability and interactions. However, many proteins contain binding regions with a high net charge that may destabilize the protein but are useful for binding to oppositely charged targets. We hypothesized that these domains wo...

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Detalles Bibliográficos
Autores principales: Jaramillo‐Martinez, Valeria, Dominguez, Matthew J., Bell, Gemma M., Souness, Megan E., Carhart, Anna H., Cuibus, M. Adriana, Masoumzadeh, Elahe, Lantz, Benjamin J., Adkins, Aaron J., Latham, Michael P., Ball, K. Aurelia, Stollar, Elliott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108434/
https://www.ncbi.nlm.nih.gov/pubmed/36992534
http://dx.doi.org/10.1002/pro.4635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108434/
https://www.ncbi.nlm.nih.gov/pubmed/36992534
http://dx.doi.org/10.1002/pro.4635

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