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Improved analysis of (e)CLIP data with RCRUNCH yields a compendium of RNA-binding protein binding sites and motifs

We present RCRUNCH, an end-to-end solution to CLIP data analysis for identification of binding sites and sequence specificity of RNA-binding proteins. RCRUNCH can analyze not only reads that map uniquely to the genome but also those that map to multiple genome locations or across splice boundaries a...

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Detalles Bibliográficos
Autores principales: Katsantoni, Maria, van Nimwegen, Erik, Zavolan, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108518/
https://www.ncbi.nlm.nih.gov/pubmed/37069586
http://dx.doi.org/10.1186/s13059-023-02913-0