Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes

BACKGROUND: Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure. We aim to clarify molecular mechanisms of TKI-induced cardiotoxicity so as to find potential targets for treating the...

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Detalles Bibliográficos
Autores principales: Wang, Huan, Wang, Yiming, Li, Jiongyuan, He, Ziyi, Boswell, Sarah A., Chung, Mirra, You, Fuping, Han, Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108821/
https://www.ncbi.nlm.nih.gov/pubmed/37069550
http://dx.doi.org/10.1186/s12916-023-02838-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108821/
https://www.ncbi.nlm.nih.gov/pubmed/37069550
http://dx.doi.org/10.1186/s12916-023-02838-2

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