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Three tyrosine kinase inhibitors cause cardiotoxicity by inducing endoplasmic reticulum stress and inflammation in cardiomyocytes
BACKGROUND: Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure. We aim to clarify molecular mechanisms of TKI-induced cardiotoxicity so as to find potential targets for treating the...
Autores principales: | Wang, Huan, Wang, Yiming, Li, Jiongyuan, He, Ziyi, Boswell, Sarah A., Chung, Mirra, You, Fuping, Han, Sen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10108821/ https://www.ncbi.nlm.nih.gov/pubmed/37069550 http://dx.doi.org/10.1186/s12916-023-02838-2 |
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