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O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea

INTRODUCTION: The mechanism underlying the development of excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) remains unclear. Thus, we characterised the association between sleep architecture and EDS in individuals with and without OSA. METHODS: 1876 suspected OSA patients reporting...

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Autores principales: Chen, X, Korkalainen, H, Kainulainen, S, Leppänen, T, Oksenberg, A, Töyräs, J, Terrill, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109005/
http://dx.doi.org/10.1093/sleepadvances/zpac029.028
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author Chen, X
Korkalainen, H
Kainulainen, S
Leppänen, T
Oksenberg, A
Töyräs, J
Terrill, P
author_facet Chen, X
Korkalainen, H
Kainulainen, S
Leppänen, T
Oksenberg, A
Töyräs, J
Terrill, P
author_sort Chen, X
collection PubMed
description INTRODUCTION: The mechanism underlying the development of excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) remains unclear. Thus, we characterised the association between sleep architecture and EDS in individuals with and without OSA. METHODS: 1876 suspected OSA patients reporting daytime sleepiness underwent in-lab polysomnography and next-day multiple sleep latency test (MSLT). We investigated sleep architecture characteristics in OSA (apnea-hypopnea index [AHI]≥5, n=1508) and non-OSA (AHI<5, n=368) patients with and without EDS (MSLT≤10-minutes and MSLT>10-minutes). Sleep architecture was quantified by N1, N2, N3, REM, total sleep time (TST), and wake after sleep onset (WASO). RESULTS: OSA patients with EDS had less N1 (median: 10.0 vs 12.0-minutes, p<0.05) and N3 (60.2 vs 71.5-minutes, p<0.05) sleep, less WASO (43.0 vs 51.0-minutes, p<0.05), more N2 (210.5 vs 189.0-minutes, p<0.05) sleep, and higher TST (365.0 vs 351.5-minutes, p<0.05) than non-EDS patients. No difference was observed in the amount of REM (70.0 vs 67.5-minutes, p=0.46) sleep. Non-OSA patients with EDS had less WASO (31.5 vs 40.0-minutes, p<0.05), more N2 (188.5 vs 177.5-minutes, p<0.05) sleep, and higher TST (374.5 vs 359.0-minutes, p<0.05) and the amount of REM sleep (76.5 vs 68.5-minutes, p<0.05) than non-EDS patients. DISCUSSION: While EDS was associated with less WASO and greater TST and N2 in both OSA and non-OSA groups, there was also characteristic differences. Non-OSA patients with EDS have greater REM sleep duration, while OSA patients with EDS have less N3 sleep. There is likely a complex bi-directional relationship between sleep architecture and EDS reflecting acute/chronic sleep disruption and compensatory mechanisms.
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spelling pubmed-101090052023-05-15 O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea Chen, X Korkalainen, H Kainulainen, S Leppänen, T Oksenberg, A Töyräs, J Terrill, P Sleep Adv ORAL PRESENTATIONS INTRODUCTION: The mechanism underlying the development of excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) remains unclear. Thus, we characterised the association between sleep architecture and EDS in individuals with and without OSA. METHODS: 1876 suspected OSA patients reporting daytime sleepiness underwent in-lab polysomnography and next-day multiple sleep latency test (MSLT). We investigated sleep architecture characteristics in OSA (apnea-hypopnea index [AHI]≥5, n=1508) and non-OSA (AHI<5, n=368) patients with and without EDS (MSLT≤10-minutes and MSLT>10-minutes). Sleep architecture was quantified by N1, N2, N3, REM, total sleep time (TST), and wake after sleep onset (WASO). RESULTS: OSA patients with EDS had less N1 (median: 10.0 vs 12.0-minutes, p<0.05) and N3 (60.2 vs 71.5-minutes, p<0.05) sleep, less WASO (43.0 vs 51.0-minutes, p<0.05), more N2 (210.5 vs 189.0-minutes, p<0.05) sleep, and higher TST (365.0 vs 351.5-minutes, p<0.05) than non-EDS patients. No difference was observed in the amount of REM (70.0 vs 67.5-minutes, p=0.46) sleep. Non-OSA patients with EDS had less WASO (31.5 vs 40.0-minutes, p<0.05), more N2 (188.5 vs 177.5-minutes, p<0.05) sleep, and higher TST (374.5 vs 359.0-minutes, p<0.05) and the amount of REM sleep (76.5 vs 68.5-minutes, p<0.05) than non-EDS patients. DISCUSSION: While EDS was associated with less WASO and greater TST and N2 in both OSA and non-OSA groups, there was also characteristic differences. Non-OSA patients with EDS have greater REM sleep duration, while OSA patients with EDS have less N3 sleep. There is likely a complex bi-directional relationship between sleep architecture and EDS reflecting acute/chronic sleep disruption and compensatory mechanisms. Oxford University Press 2022-11-09 /pmc/articles/PMC10109005/ http://dx.doi.org/10.1093/sleepadvances/zpac029.028 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle ORAL PRESENTATIONS
Chen, X
Korkalainen, H
Kainulainen, S
Leppänen, T
Oksenberg, A
Töyräs, J
Terrill, P
O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title_full O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title_fullStr O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title_full_unstemmed O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title_short O029 Sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
title_sort o029 sleep architecture differs for individuals manifesting excessive daytime sleepiness with and without obstructive sleep apnea
topic ORAL PRESENTATIONS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10109005/
http://dx.doi.org/10.1093/sleepadvances/zpac029.028
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