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Omicsynin B4 potently blocks coronavirus infection by inhibiting host proteases cathepsin L and TMPRSS2

The emergence of SARS-CoV-2 variants represents a major threat to public health and requires identification of novel therapeutic agents to address the unmet medical needs. Small molecules impeding viral entry through inhibition of spike protein priming proteases could have potent antiviral effects a...

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Detalles Bibliográficos
Autores principales: Li, Yihua, Wang, Kun, Sun, Hongmin, Wu, Shuo, Wang, Huiqiang, Shi, Yuanyuan, Li, Xingxing, Yan, Haiyan, Yang, Ge, Wu, Mengyuan, Li, Yihong, Ding, Xiaotian, Si, Shuyi, Jiang, Jiandong, Du, Yu, Li, Yuhuan, Hong, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110284/
https://www.ncbi.nlm.nih.gov/pubmed/37076089
http://dx.doi.org/10.1016/j.antiviral.2023.105606