16p11.2 deletion accelerates subpallial maturation and increases variability in human iPSC-derived ventral telencephalic organoids

Inhibitory interneurons regulate cortical circuit activity, and their dysfunction has been implicated in autism spectrum disorder (ASD). 16p11.2 microdeletions are genetically linked to 1% of ASD cases. However, few studies investigate the effects of this microdeletion on interneuron development. Us...

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Detalles Bibliográficos
Autores principales: Fetit, Rana, Barbato, Michela Ilaria, Theil, Thomas, Pratt, Thomas, Price, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Human Development
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110424/
https://www.ncbi.nlm.nih.gov/pubmed/36826401
http://dx.doi.org/10.1242/dev.201227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110424/
https://www.ncbi.nlm.nih.gov/pubmed/36826401
http://dx.doi.org/10.1242/dev.201227

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