Single-cell RNA-based phenotyping reveals a pivotal role of thyroid hormone receptor alpha for hypothalamic development

Thyroid hormone and its receptor TRα1 play an important role in brain development. Several animal models have been used to investigate this function, including mice heterozygous for the TRα1R384C mutation, which confers receptor-mediated hypothyroidism. These mice display abnormalities in several au...

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Detalles Bibliográficos
Autores principales: Sreenivasan, Varun K. A., Dore, Riccardo, Resch, Julia, Maier, Julia, Dietrich, Carola, Henck, Jana, Balachandran, Saranya, Mittag, Jens, Spielmann, Malte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110490/
https://www.ncbi.nlm.nih.gov/pubmed/36715020
http://dx.doi.org/10.1242/dev.201228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110490/
https://www.ncbi.nlm.nih.gov/pubmed/36715020
http://dx.doi.org/10.1242/dev.201228

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