A spirocyclic backbone accesses new conformational space in an extended, dipole-stabilized foldamer

Most aromatic foldamers adopt uniform secondary structures, offering limited potential for the exploration of conformational space and the formation of tertiary structures. Here we report the incorporation of spiro bis-lactams to allow controlled rotation of the backbone of an iteratively synthesise...

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Detalles Bibliográficos
Autores principales: Roe, William Edward, Warnock, Toyah Mary Catherine, Knipe, Peter Clarke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110530/
https://www.ncbi.nlm.nih.gov/pubmed/37069245
http://dx.doi.org/10.1038/s42004-023-00868-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110530/
https://www.ncbi.nlm.nih.gov/pubmed/37069245
http://dx.doi.org/10.1038/s42004-023-00868-8

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