Hsp90 provides a platform for kinase dephosphorylation by PP5

The Hsp90 molecular chaperone collaborates with the phosphorylated Cdc37 cochaperone for the folding and activation of its many client kinases. As with many kinases, the Hsp90 client kinase CRaf is activated by phosphorylation at specific regulatory sites. The cochaperone phosphatase PP5 dephosphory...

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Detalles Bibliográficos
Autores principales: Jaime-Garza, Maru, Nowotny, Carlos A., Coutandin, Daniel, Wang, Feng, Tabios, Mariano, Agard, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110553/
https://www.ncbi.nlm.nih.gov/pubmed/37069154
http://dx.doi.org/10.1038/s41467-023-37659-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110553/
https://www.ncbi.nlm.nih.gov/pubmed/37069154
http://dx.doi.org/10.1038/s41467-023-37659-7

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