Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model

Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the maternally expressed UBE3A gene. Treatments for the main manifestations, including cognitive dysfunction or epilepsy, are still under development. Recently, the Cl(−) importer Na(+)-K(+)-Cl(−) cotransporter 1 (NKCC1...

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Detalles Bibliográficos
Autores principales: Egawa, Kiyoshi, Watanabe, Miho, Shiraishi, Hideaki, Sato, Daisuke, Takahashi, Yukitoshi, Nishio, Saori, Fukuda, Atsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110603/
https://www.ncbi.nlm.nih.gov/pubmed/37069177
http://dx.doi.org/10.1038/s41598-023-32376-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110603/
https://www.ncbi.nlm.nih.gov/pubmed/37069177
http://dx.doi.org/10.1038/s41598-023-32376-z

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