The 3′UTR region of the DNA repair gene PARP-1 May increase the severity of COVID-19 by altering the binding of antiviral miRNAs

COVID-19 may cause the release of systemic inflammatory cytokines resulting in severe inflammation. PARP-1 has been identified as a nuclear enzyme that is activated by DNA strand breaks. It has been suggested that PARP-1 has a role in the cytokine storm shown as a cause of mortality in COVID-19, and...

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Detalles Bibliográficos
Autores principales: Yılmaz, Büşra, Çakmak Genç, Güneş, Karakaş Çelik, Sevim, Pişkin, Nihal, Horuz, Emre, DURSUN, Ahmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110933/
https://www.ncbi.nlm.nih.gov/pubmed/37087842
http://dx.doi.org/10.1016/j.virol.2023.04.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110933/
https://www.ncbi.nlm.nih.gov/pubmed/37087842
http://dx.doi.org/10.1016/j.virol.2023.04.005

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