Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions

The manufacturing of antibody-drug conjugates (ADCs) involves the addition of a cytotoxic small-molecule linker-drug (= payload) to a solution of functionalized antibodies. For the development of robust conjugation processes, initially small-scale reaction tubes are used which requires a lot of manu...

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Detalles Bibliográficos
Autores principales: Weggen, Jan Tobias, Seidel, Janik, Bean, Ryan, Wendeler, Michaela, Hubbuch, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111256/
https://www.ncbi.nlm.nih.gov/pubmed/37082211
http://dx.doi.org/10.3389/fbioe.2023.1123842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111256/
https://www.ncbi.nlm.nih.gov/pubmed/37082211
http://dx.doi.org/10.3389/fbioe.2023.1123842

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