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Kinetic studies and CFD-based reaction modeling for insights into the scalability of ADC conjugation reactions
The manufacturing of antibody-drug conjugates (ADCs) involves the addition of a cytotoxic small-molecule linker-drug (= payload) to a solution of functionalized antibodies. For the development of robust conjugation processes, initially small-scale reaction tubes are used which requires a lot of manu...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111256/ https://www.ncbi.nlm.nih.gov/pubmed/37082211 http://dx.doi.org/10.3389/fbioe.2023.1123842 |