Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo

A dysregulated plasma contact system is involved in various pathological conditions, such as hereditary angioedema, Alzheimer disease, and sepsis. We previously showed that the 3E8 anti–high molecular weight kininogen (anti-HK) antibody blocks HK cleavage and bradykinin generation in human plasma ex...

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Detalles Bibliográficos
Autores principales: Chen, Zu-Lin, Singh, Pradeep K., Horn, Katharina, Calvano, Marissa R., Kaneki, Shigeru, McCrae, Keith R., Strickland, Sidney, Norris, Erin H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111358/
https://www.ncbi.nlm.nih.gov/pubmed/36409609
http://dx.doi.org/10.1182/bloodadvances.2021006485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111358/
https://www.ncbi.nlm.nih.gov/pubmed/36409609
http://dx.doi.org/10.1182/bloodadvances.2021006485

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