Antimalarial Imidazopyridines Incorporating an Intramolecular Hydrogen Bonding Motif: Medicinal Chemistry and Mechanistic Studies

[Image: see text] We previously identified a novel class of antimalarial benzimidazoles incorporating an intramolecular hydrogen bonding motif. The frontrunner of the series, analogue A, showed nanomolar activity against the chloroquine-sensitive NF54 and multi-drug-resistant K1 strains of Plasmodiu...

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Detalles Bibliográficos
Autores principales: Attram, Henrietta D., Korkor, Constance M., Taylor, Dale, Njoroge, Mathew, Chibale, Kelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111423/
https://www.ncbi.nlm.nih.gov/pubmed/36946433
http://dx.doi.org/10.1021/acsinfecdis.2c00584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111423/
https://www.ncbi.nlm.nih.gov/pubmed/36946433
http://dx.doi.org/10.1021/acsinfecdis.2c00584

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