Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis

BACKGROUND: Elucidating compound mechanism of action (MoA) is beneficial to drug discovery, but in practice often represents a significant challenge. Causal Reasoning approaches aim to address this situation by inferring dysregulated signalling proteins using transcriptomics data and biological netw...

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Detalles Bibliográficos
Autores principales: Hosseini-Gerami, Layla, Higgins, Ixavier Alonzo, Collier, David A., Laing, Emma, Evans, David, Broughton, Howard, Bender, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111792/
https://www.ncbi.nlm.nih.gov/pubmed/37072707
http://dx.doi.org/10.1186/s12859-023-05277-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111792/
https://www.ncbi.nlm.nih.gov/pubmed/37072707
http://dx.doi.org/10.1186/s12859-023-05277-1

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