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Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis
BACKGROUND: Elucidating compound mechanism of action (MoA) is beneficial to drug discovery, but in practice often represents a significant challenge. Causal Reasoning approaches aim to address this situation by inferring dysregulated signalling proteins using transcriptomics data and biological netw...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111792/ https://www.ncbi.nlm.nih.gov/pubmed/37072707 http://dx.doi.org/10.1186/s12859-023-05277-1 |