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ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease
Although it is well established that Huntington's disease (HD) is mainly caused by polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT-mediated actions is not fully understood. Here, we showed that expression of the N-terminal fragment containing the expanded polygl...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111862/ https://www.ncbi.nlm.nih.gov/pubmed/36921996 http://dx.doi.org/10.1101/gad.350211.122 |