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ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington's disease

Although it is well established that Huntington's disease (HD) is mainly caused by polyglutamine-expanded mutant huntingtin (mHTT), the molecular mechanism of mHTT-mediated actions is not fully understood. Here, we showed that expression of the N-terminal fragment containing the expanded polygl...

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Detalles Bibliográficos
Autores principales:	Song, Shujuan, Su, Zhenyi, Kon, Ning, Chu, Bo, Li, Huan, Jiang, Xuejun, Luo, Jianyuan, Stockwell, Brent R., Gu, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2023
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111862/ https://www.ncbi.nlm.nih.gov/pubmed/36921996 http://dx.doi.org/10.1101/gad.350211.122

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