Effect of an Antacid (Aluminum Hydroxide/Magnesium Hydroxide/Simethicone) or a Proton Pump Inhibitor (Omeprazole) on the Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Adult Subjects

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is a novel oral carbapenem prodrug being developed for the treatment of serious bacterial infections. This open-label, 3-period, fixed sequence study evaluated the effect of gastric acid-reducing agents, aluminum hydroxide/magnesium hydroxide/simethicone,...

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Detalles Bibliográficos
Autores principales: Patel, Gina, Gupta, Vipul K., Gasink, Leanne, Bajraktari, Floni, Lei, Yang, Jain, Akash, Srivastava, Praveen, Talley, Angela K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112192/
https://www.ncbi.nlm.nih.gov/pubmed/36943038
http://dx.doi.org/10.1128/aac.01495-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112192/
https://www.ncbi.nlm.nih.gov/pubmed/36943038
http://dx.doi.org/10.1128/aac.01495-22

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