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Effect of an Antacid (Aluminum Hydroxide/Magnesium Hydroxide/Simethicone) or a Proton Pump Inhibitor (Omeprazole) on the Pharmacokinetics of Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) in Healthy Adult Subjects

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is a novel oral carbapenem prodrug being developed for the treatment of serious bacterial infections. This open-label, 3-period, fixed sequence study evaluated the effect of gastric acid-reducing agents, aluminum hydroxide/magnesium hydroxide/simethicone,...

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Detalles Bibliográficos
Autores principales:	Patel, Gina, Gupta, Vipul K., Gasink, Leanne, Bajraktari, Floni, Lei, Yang, Jain, Akash, Srivastava, Praveen, Talley, Angela K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112192/ https://www.ncbi.nlm.nih.gov/pubmed/36943038 http://dx.doi.org/10.1128/aac.01495-22

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