A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14

TAS2Rs (bitter taste receptors) are GPCRs (G protein–coupled receptors) expressed on human airway smooth muscle (HASM) cells; when activated by receptor agonists they evoke marked airway relaxation. In both taste and HASM cells, TAS2Rs activate a canonical G(βγ)-mediated stimulation of Ca(2+) releas...

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Detalles Bibliográficos
Autores principales: Woo, Jung-A A., Castaño, Maria, Kee, Teresa R., Lee, Jordan, Koziol-White, Cynthia J., An, Steven S., Kim, Donghwa, Kang, David E., Liggett, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Thoracic Society 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112429/
https://www.ncbi.nlm.nih.gov/pubmed/36662576
http://dx.doi.org/10.1165/rcmb.2022-0303OC

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112429/
https://www.ncbi.nlm.nih.gov/pubmed/36662576
http://dx.doi.org/10.1165/rcmb.2022-0303OC

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