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A Par3/LIM Kinase/Cofilin Pathway Mediates Human Airway Smooth Muscle Relaxation by TAS2R14

TAS2Rs (bitter taste receptors) are GPCRs (G protein–coupled receptors) expressed on human airway smooth muscle (HASM) cells; when activated by receptor agonists they evoke marked airway relaxation. In both taste and HASM cells, TAS2Rs activate a canonical G(βγ)-mediated stimulation of Ca(2+) releas...

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Detalles Bibliográficos
Autores principales:	Woo, Jung-A A., Castaño, Maria, Kee, Teresa R., Lee, Jordan, Koziol-White, Cynthia J., An, Steven S., Kim, Donghwa, Kang, David E., Liggett, Stephen B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Thoracic Society 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112429/ https://www.ncbi.nlm.nih.gov/pubmed/36662576 http://dx.doi.org/10.1165/rcmb.2022-0303OC

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