Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, and in silico studies

In this article, we continued our previous effort to develop new selective anticancer candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 inhibitors. Therefore, twenty-two novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives were designed and examined as d...

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Detalles Bibliográficos
Autores principales: Al-Muntaser, Samia M., Al-Karmalawy, Ahmed A., El-Naggar, Abeer M., Ali, Ali Khalil, Abd El-Sattar, Nour E. A., Abbass, Eslam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112504/
https://www.ncbi.nlm.nih.gov/pubmed/37082377
http://dx.doi.org/10.1039/d3ra00416c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112504/
https://www.ncbi.nlm.nih.gov/pubmed/37082377
http://dx.doi.org/10.1039/d3ra00416c

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