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Effects of chemokine (C-C motif) receptor 2 and 3 antagonists in rat models of hemorrhagic shock

Systemic concentrations of chemokine CCL2, an agonist at chemokine receptors CCR2/3/5, have been associated with hemodynamic instability after traumatic-hemorrhagic shock. We reported previously that the CCR2 antagonist INCB3284 prevents cardiovascular collapse and reduces fluid requirements after 3...

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Detalles Bibliográficos
Autores principales: Weche, McWayne, DeSantis, Anthony J., McGee, Michelle Y., Enten, Garrett A., Gao, Xianlong, Majetschak, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112773/
https://www.ncbi.nlm.nih.gov/pubmed/37071651
http://dx.doi.org/10.1371/journal.pone.0284472