Development and Application of a Liquid Chromatography-Mass Spectrometry Method for Residual Iodixanol Quantification in AAV-Based Gene Therapy Product Development

Adeno-associated viruses (AAVs) are nonenveloped viruses that have become popular gene transfer vectors to deliver DNA to target cells in clinical gene therapy. Iodixanol-based density gradient is one of the widely used purification methods for serotype-independent AAVs. However, residual iodixanol...

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Detalles Bibliográficos
Autores principales: Pu, Yi, Katz, Russell, Chen, Yunqiu, Kostrubsky, Vic, Clarner, Pete, Lo, Shih-Ching, Sosic, Zoran, Yeung, Bernice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112872/
https://www.ncbi.nlm.nih.gov/pubmed/34376063
http://dx.doi.org/10.1089/hum.2021.136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112872/
https://www.ncbi.nlm.nih.gov/pubmed/34376063
http://dx.doi.org/10.1089/hum.2021.136

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