Multimodular Optimization of Chemically Regulated T Cell Switches Demonstrates Flexible and Interchangeable Nature of Immune Cell Signaling Domains

Immune cell-based therapies can induce potent antitumor effects but are also often associated with severe toxicities. We previously developed a PD-1-based small molecule-regulated reversible T cell activation switch to control the activity of cellular immunotherapy products. This chemically regulate...

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Detalles Bibliográficos
Autores principales: Sahillioglu, Ali Can, Schumacher, Ton N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112874/
https://www.ncbi.nlm.nih.gov/pubmed/34662227
http://dx.doi.org/10.1089/hum.2021.148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112874/
https://www.ncbi.nlm.nih.gov/pubmed/34662227
http://dx.doi.org/10.1089/hum.2021.148

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