The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system

Abnormalities in the endosomal-autophagic-lysosomal (EAL) system are an early event in Alzheimer's disease (AD) pathogenesis. However, the mechanisms underlying these abnormalities are unclear. The transient receptor potential channel mucolipin 1(TRPML1, also known as MCOLN1), a vital endosomal...

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Detalles Bibliográficos
Autores principales: Somogyi, Aleksandra, Kirkham, Emily D., Lloyd-Evans, Emyr, Winston, Jincy, Allen, Nicholas D., Mackrill, John J., Anderson, Karen E., Hawkins, Phillip T., Gardiner, Sian E., Waller-Evans, Helen, Sims, Rebecca, Boland, Barry, O'Neill, Cora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112969/
https://www.ncbi.nlm.nih.gov/pubmed/36825945
http://dx.doi.org/10.1242/jcs.259875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10112969/
https://www.ncbi.nlm.nih.gov/pubmed/36825945
http://dx.doi.org/10.1242/jcs.259875

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