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Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation

PURPOSE: The aim of this study is to investigate changes in choroidal and optic nerve morphological parameters following MicroShunt PreserFlo implantation. The secondary aim is to investigate how the structural changes relate to the decrease in intraocular pressure (IOP). METHODS: Prospective observ...

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Autores principales: Gambini, Gloria, Carlà, Matteo Mario, Caporossi, Tomaso, Baldascino, Antonio, Crincoli, Emanuele, De Vico, Umberto, Savastano, Alfonso, Caporossi, Aldo, Rizzo, Stanislao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113179/
https://www.ncbi.nlm.nih.gov/pubmed/36129605
http://dx.doi.org/10.1007/s10792-022-02519-8
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author Gambini, Gloria
Carlà, Matteo Mario
Caporossi, Tomaso
Baldascino, Antonio
Crincoli, Emanuele
De Vico, Umberto
Savastano, Alfonso
Caporossi, Aldo
Rizzo, Stanislao
author_facet Gambini, Gloria
Carlà, Matteo Mario
Caporossi, Tomaso
Baldascino, Antonio
Crincoli, Emanuele
De Vico, Umberto
Savastano, Alfonso
Caporossi, Aldo
Rizzo, Stanislao
author_sort Gambini, Gloria
collection PubMed
description PURPOSE: The aim of this study is to investigate changes in choroidal and optic nerve morphological parameters following MicroShunt PreserFlo implantation. The secondary aim is to investigate how the structural changes relate to the decrease in intraocular pressure (IOP). METHODS: Prospective observational study on 15 eyes with glaucoma requiring MicroShunt implantation. Optical coherence tomography was used to measure macular choroidal thickness (MCT), peripapillary choroidal thickness (PCT), lamina cribrosa depth (LCD), cup depth and prelaminar tissue thickness (PLT), before and one day after surgery. Results were expressed in median and interquartile range (IQR) and correlated with IOP results. RESULTS: The IOP decreased from a median of 25 (IQR = 11) mmHg to 8 (IQR = 2) mmHg the day after surgery. Median MCT increased after MicroShunt implantation from 252.1 (IQR = 156.4) µm to a postoperative value of 318.1 (IQR = 166.6) µm (p < 0.001), with a median increase of + 87.7 µm (+ 26.4%). PCT increased from 157.2 (IQR = 109.1) µm before surgery to 206.0 (IQR = 136.1) µm after surgery (p < 0.001). Moreover, we found a significant post-operative decrease in cup depth (median reduction of − 29.3 µm, p < 0.001) and an increase in PLT (median increase of 27.3 µm, p = 0.028). On the other side, LCD reduction 24 h after surgery didn’t reach any statistical significance. CONCLUSION: PreserFlo implantation determines retinal structural changes which appear similar to those caused by traditional filtering surgery, confirming the effectiveness of this device, meantime carrying a much smaller complications rate when compared to trabeculectomy.
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spelling pubmed-101131792023-04-20 Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation Gambini, Gloria Carlà, Matteo Mario Caporossi, Tomaso Baldascino, Antonio Crincoli, Emanuele De Vico, Umberto Savastano, Alfonso Caporossi, Aldo Rizzo, Stanislao Int Ophthalmol Original Paper PURPOSE: The aim of this study is to investigate changes in choroidal and optic nerve morphological parameters following MicroShunt PreserFlo implantation. The secondary aim is to investigate how the structural changes relate to the decrease in intraocular pressure (IOP). METHODS: Prospective observational study on 15 eyes with glaucoma requiring MicroShunt implantation. Optical coherence tomography was used to measure macular choroidal thickness (MCT), peripapillary choroidal thickness (PCT), lamina cribrosa depth (LCD), cup depth and prelaminar tissue thickness (PLT), before and one day after surgery. Results were expressed in median and interquartile range (IQR) and correlated with IOP results. RESULTS: The IOP decreased from a median of 25 (IQR = 11) mmHg to 8 (IQR = 2) mmHg the day after surgery. Median MCT increased after MicroShunt implantation from 252.1 (IQR = 156.4) µm to a postoperative value of 318.1 (IQR = 166.6) µm (p < 0.001), with a median increase of + 87.7 µm (+ 26.4%). PCT increased from 157.2 (IQR = 109.1) µm before surgery to 206.0 (IQR = 136.1) µm after surgery (p < 0.001). Moreover, we found a significant post-operative decrease in cup depth (median reduction of − 29.3 µm, p < 0.001) and an increase in PLT (median increase of 27.3 µm, p = 0.028). On the other side, LCD reduction 24 h after surgery didn’t reach any statistical significance. CONCLUSION: PreserFlo implantation determines retinal structural changes which appear similar to those caused by traditional filtering surgery, confirming the effectiveness of this device, meantime carrying a much smaller complications rate when compared to trabeculectomy. Springer Netherlands 2022-09-21 2023 /pmc/articles/PMC10113179/ /pubmed/36129605 http://dx.doi.org/10.1007/s10792-022-02519-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Gambini, Gloria
Carlà, Matteo Mario
Caporossi, Tomaso
Baldascino, Antonio
Crincoli, Emanuele
De Vico, Umberto
Savastano, Alfonso
Caporossi, Aldo
Rizzo, Stanislao
Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title_full Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title_fullStr Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title_full_unstemmed Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title_short Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation
title_sort early evaluation of optic nerve head morphology and choroidal thickness after preserflo microshunt implantation
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113179/
https://www.ncbi.nlm.nih.gov/pubmed/36129605
http://dx.doi.org/10.1007/s10792-022-02519-8
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