Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation

The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both indivi...

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Detalles Bibliográficos
Autores principales: Hughes, Laetitia A., Rudler, Danielle L., Siira, Stefan J., McCubbin, Tim, Raven, Samuel A., Browne, Jasmin M., Ermer, Judith A., Rientjes, Jeanette, Rodger, Jennifer, Marcellin, Esteban, Rackham, Oliver, Filipovska, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113395/
https://www.ncbi.nlm.nih.gov/pubmed/37072429
http://dx.doi.org/10.1038/s41467-023-37843-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113395/
https://www.ncbi.nlm.nih.gov/pubmed/37072429
http://dx.doi.org/10.1038/s41467-023-37843-9

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