Cargando…
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both indivi...
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113395/ https://www.ncbi.nlm.nih.gov/pubmed/37072429 http://dx.doi.org/10.1038/s41467-023-37843-9 |