CD28-signaling can be partially compensated in CD28-knockout mice but is essential for virus elimination in a murine model of multiple sclerosis

The intracerebral infection of mice with Theiler’s murine encephalomyelitis virus (TMEV) represents a well-established animal model for multiple sclerosis (MS). Because CD28 is the main co-stimulatory molecule for the activation of T cells, we wanted to investigate its impact on the course of the vi...

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Detalles Bibliográficos
Autores principales: Hülskötter, Kirsten, Lühder, Fred, Leitzen, Eva, Flügel, Alexander, Baumgärtner, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113529/
https://www.ncbi.nlm.nih.gov/pubmed/37090733
http://dx.doi.org/10.3389/fimmu.2023.1105432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10113529/
https://www.ncbi.nlm.nih.gov/pubmed/37090733
http://dx.doi.org/10.3389/fimmu.2023.1105432

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