LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice

OBJECTIVES: Some histone deacetylase (HDAC) isoforms contribute to ischaemia/reperfusion (IR) injury (IRI). Here, we examined whether LP342, the lead candidate of a new generation of hydrazide-based HDAC inhibitors (HDACi), decreases hepatic IRI. METHODS: IR was induced by clamping blood vessels to...

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Detalles Bibliográficos
Autores principales: Samuvel, Devadoss J, Krishnasamy, Yasodha, Li, Li, Lemasters, John J, Chou, C James, Zhong, Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114105/
https://www.ncbi.nlm.nih.gov/pubmed/37092117
http://dx.doi.org/10.1093/rpsppr/rqad013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114105/
https://www.ncbi.nlm.nih.gov/pubmed/37092117
http://dx.doi.org/10.1093/rpsppr/rqad013

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