Cargando…

Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain

Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells for application in disease modeling, diagnostics, drug screening and cell-based therapies for Parkinson's disease. An increased understanding of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Birtele, Marcella, Storm, Petter, Sharma, Yogita, Kajtez, Janko, Wahlestedt, Jenny Nelander, Sozzi, Edoardo, Nilsson, Fredrik, Stott, Simon, He, Xiaoling L., Mattsson, Bengt, Ottosson, Daniella Rylander, Barker, Roger A., Fiorenzano, Alessandro, Parmar, Malin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Human Development
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114107/ https://www.ncbi.nlm.nih.gov/pubmed/36305490 http://dx.doi.org/10.1242/dev.200504

Ejemplares similares

Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
por: Fiorenzano, Alessandro, et al.
Publicado: (2021)

Author Correction: Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
por: Fiorenzano, Alessandro, et al.
Publicado: (2022)

Silk scaffolding drives self-assembly of functional and mature human brain organoids
por: Sozzi, Edoardo, et al.
Publicado: (2022)

Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons
por: Fiorenzano, Alessandro, et al.
Publicado: (2021)

Protocol for optical clearing and imaging of fluorescently labeled ex vivo rat brain slices
por: Giacomoni, Jessica, et al.
Publicado: (2023)

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons
por: Nolbrant, Sara, et al.
Publicado: (2020)

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation
por: Nilsson, Fredrik, et al.
Publicado: (2021)

Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease
por: Drouin-Ouellet, Janelle, et al.
Publicado: (2022)

Dopamine Neuron Diversity: Recent Advances and Current Challenges in Human Stem Cell Models and Single Cell Sequencing
por: Fiorenzano, Alessandro, et al.
Publicado: (2021)

Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease
por: Shrigley, Shelby, et al.
Publicado: (2021)

Target‐specific forebrain projections and appropriate synaptic inputs of hESC‐derived dopamine neurons grafted to the midbrain of parkinsonian rats
por: Cardoso, Tiago, et al.
Publicado: (2018)

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease
por: Adler, Andrew F., et al.
Publicado: (2019)

Direct Reprogramming of Resident NG2 Glia into Neurons with Properties of Fast-Spiking Parvalbumin-Containing Interneurons
por: Pereira, Maria, et al.
Publicado: (2017)

Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs
por: Kajtez, Janko, et al.
Publicado: (2022)

Embedded 3D Printing in Self‐Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs (Adv. Sci. 25/2022)
por: Kajtez, Janko, et al.
Publicado: (2022)

Direct reprogramming into interneurons: potential for brain repair
por: Pereira, Maria, et al.
Publicado: (2019)

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD
por: Hoban, Deirdre B., et al.
Publicado: (2020)

Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids
por: Shang, Jia, et al.
Publicado: (2022)

High-throughput generation of midbrain dopaminergic neuron organoids from reporter human pluripotent stem cells
por: Sarrafha, Lily, et al.
Publicado: (2021)

Acquisition of the Midbrain Dopaminergic Neuronal Identity
por: Mesman, Simone, et al.
Publicado: (2020)

In Vivo Reprogramming of Striatal NG2 Glia into Functional Neurons that Integrate into Local Host Circuitry
por: Torper, Olof, et al.
Publicado: (2015)

3D‐Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices
por: Kajtez, Janko, et al.
Publicado: (2020)

3D‐Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices
por: Kajtez, Janko, et al.
Publicado: (2021)

Lewy Body-like Pathology and Loss of Dopaminergic Neurons in Midbrain Organoids Derived from Familial Parkinson’s Disease Patient
por: Becerra-Calixto, Andrea, et al.
Publicado: (2023)

Rhythmic oscillations in the midbrain dopaminergic nuclei in mice
por: Oberto, Virginie J., et al.
Publicado: (2023)

Modeling Parkinson’s disease in midbrain-like organoids
por: Smits, Lisa M., et al.
Publicado: (2019)

Sonic Hedgehog Is a Chemoattractant for Midbrain Dopaminergic Axons
por: Hammond, Rachel, et al.
Publicado: (2009)

Disrupted Functional Connectivity with Dopaminergic Midbrain in Cocaine Abusers
por: Tomasi, Dardo, et al.
Publicado: (2010)

From 2D to 3D: Development of Monolayer Dopaminergic Neuronal and Midbrain Organoid Cultures for Parkinson’s Disease Modeling and Regenerative Therapy
por: Yeap, Yee Jie, et al.
Publicado: (2023)

Striatal Plasticity in L-DOPA- and Graft-Induced Dyskinesia; The Common Link?
por: Rylander Ottosson, Daniella, et al.
Publicado: (2016)

A robust protocol for the generation of human midbrain organoids
por: Zagare, Alise, et al.
Publicado: (2021)

Protocol for generating reproducible miniaturized controlled midbrain organoids
por: Chen, Muwan, et al.
Publicado: (2023)

En1 and Wnt signaling in midbrain dopaminergic neuronal development
por: Alves dos Santos, Maria TM, et al.
Publicado: (2011)

Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis
por: Ribeiro, Diogo, et al.
Publicado: (2011)

Computational model of midbrain dopaminergic neuron activity in ageing and obesity
por: Popovych, Svitlana, et al.
Publicado: (2013)

Interaction of NMDA Receptor and Pacemaking Mechanisms in the Midbrain Dopaminergic Neuron
por: Ha, Joon, et al.
Publicado: (2013)

Cortical regulation of dopaminergic neurons: role of the midbrain superior colliculus
por: Bertram, C., et al.
Publicado: (2013)

Transcriptional comparison of human induced and primary midbrain dopaminergic neurons
por: Xia, Ninuo, et al.
Publicado: (2016)

The Dopaminergic Midbrain Encodes the Expected Certainty about Desired Outcomes
por: Schwartenbeck, Philipp, et al.
Publicado: (2015)

Multiple value signals in dopaminergic midbrain and their role in avoidance contexts
por: Rigoli, Francesco, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_32ukb1m1k81s5bv7nrt3b2nd77