Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy

BACKGROUND: One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as a central mediator of resistance to MAPK-targeted therapy. Reasoning that lipogenesis-med...

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Detalles Bibliográficos
Autores principales: Talebi, Ali, de Laat, Vincent, Spotbeen, Xander, Dehairs, Jonas, Rambow, Florian, Rogiers, Aljosja, Vanderhoydonc, Frank, Rizotto, Lara, Planque, Mélanie, Doglioni, Ginevra, Motamedi, Sahar, Nittner, David, Roskams, Tania, Agostinis, Patrizia, Bechter, Oliver, Boecxstaens, Veerle, Garmyn, Marjan, O’Farrell, Marie, Wagman, Alan, Kemble, George, Leucci, Eleonora, Fendt, Sarah-Maria, Marine, Jean-Christophe, Swinnen, Johannes V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114329/
https://www.ncbi.nlm.nih.gov/pubmed/37072838
http://dx.doi.org/10.1186/s13046-023-02664-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114329/
https://www.ncbi.nlm.nih.gov/pubmed/37072838
http://dx.doi.org/10.1186/s13046-023-02664-7

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