Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

BACKGROUND: Monocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE). We sought to identify novel compounds that might serve as monocyte-directed targeted therapies in SLE. RESULTS: We performed mRNA sequencing in monocy...

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Detalles Bibliográficos
Autores principales: Nikolakis, Dimitrios, Garantziotis, Panagiotis, Sentis, George, Fanouriakis, Antonis, Bertsias, George, Frangou, Eleni, Nikolopoulos, Dionysis, Banos, Aggelos, Boumpas, Dimitrios T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114456/
https://www.ncbi.nlm.nih.gov/pubmed/37072752
http://dx.doi.org/10.1186/s12864-023-09275-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114456/
https://www.ncbi.nlm.nih.gov/pubmed/37072752
http://dx.doi.org/10.1186/s12864-023-09275-8

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