GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1

The T-lineage restricted protein THEMIS has been shown to play a critical role in T cell development. THEMIS, via its distinctive CABIT domains, inhibits the catalytic activity of the tyrosine phosphatase SHP1 (PTPN6). SHP1 and THEMIS bind to the ubiquitous cytosolic adapter GRB2, and the purported...

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Detalles Bibliográficos
Autores principales: Choi, Seeyoung, Hatzihristidis, Teri, Gaud, Guillaume, Dutta, Avik, Lee, Jan, Arya, Awadhesh, Clubb, Lauren M., Stamos, Daniel B., Markovics, Adrienn, Mikecz, Katalin, Love, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114920/
https://www.ncbi.nlm.nih.gov/pubmed/37067793
http://dx.doi.org/10.1084/jem.20221649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114920/
https://www.ncbi.nlm.nih.gov/pubmed/37067793
http://dx.doi.org/10.1084/jem.20221649

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