Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation

Lysosomal integrity is vital for cell homeostasis, but the underlying mechanisms are poorly understood. Here, we identify CLH-6, the C. elegans ortholog of the lysosomal Cl(−)/H(+) antiporter ClC-7, as an important factor for protecting lysosomal integrity. Loss of CLH-6 affects lysosomal degradatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Qianqian, Li, Yuan, Jian, Youli, Li, Meijiao, Wang, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114921/
https://www.ncbi.nlm.nih.gov/pubmed/37058288
http://dx.doi.org/10.1083/jcb.202210063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114921/
https://www.ncbi.nlm.nih.gov/pubmed/37058288
http://dx.doi.org/10.1083/jcb.202210063

Ejemplares similares